New Antibiotic Resistance Gene Was Detected in Livestock Bacteria in the USA
BLAIMP-27 antibiotic resistance gene (β-lactamase imipenemasa)
conferring resistance to carbapenems, antibiotics of one of the most important
classes, was detected in bacteria isolated from feeding pigs as well as from
swabs taken from floors and walls of pig houses and from pig feces samples.
Therewith, use of carbapenems in animals is banned in the
USA since this group of antibiotics is included in the first range of medicines
used for human treatment.
Emergence of carbapenem-resistant bacteria may result from
legal use of β-lactamase antibiotics not included in the group of carbapenems
in animal farming. Bacteria are supposed to become carbapenem-resistant due to
use of ceftiofur from group of cephalosporins.
BLAIMP-27 gene is easily transmitted from one bacterium to
another one with plasmids that are small DNA fragments. Possible incorporation
of this gene in the genome of microorganisms causing human diseases will make use
of antibiotics of carbapenem group ineffective. Carbapenems are antibiotics
applied for medical treatment of human infectious diseases. They are important
drugs for combating bacteria resistant to other antimicrobials.
Carbapenem-resistant bacteria pose a significant threat for humans as potential
agents of hospital infections. The Rosselkhoznadzor monitors the situation.